Mevalonate pyrophosphate decarboxylase in stroke-prone spontaneously hypertensive rat is reduced from the age of two weeks

Citation
A. Michihara et al., Mevalonate pyrophosphate decarboxylase in stroke-prone spontaneously hypertensive rat is reduced from the age of two weeks, BIOL PHAR B, 24(12), 2001, pp. 1417-1419
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
0918-6158 → ACNP
Volume
24
Issue
12
Year of publication
2001
Pages
1417 - 1419
Database
ISI
SICI code
0918-6158(200112)24:12<1417:MPDISS>2.0.ZU;2-H
Abstract
We carried out a comparison of tissue distribution of mevalonate pyrophosph ate decarboxylase (MPD) between normotensive Wistar Kyoto rat (WKY) and str oke-prone spontaneously hypertensive rat (SHRSP) using Western blotting. Ho wever, there was no difference in tissue distribution of MPD between WKY an d SHRSP, expect in brain and liver. We then compared the MPD between WKY an d SHRSP liver at several weeks of age. We found that MPD in the liver as we ll as brain of SHRSP was significantly reduced from two weeks of age. This data is useful to identify or understand the mechanism underlying the reduc ed amount of MPD in SHRSP.