Left-right asymmetry determination in vertebrates

Citation
M. Mercola et M. Levin, Left-right asymmetry determination in vertebrates, ANN R C DEV, 17, 2001, pp. 779-805
Citations number
147
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
17
Year of publication
2001
Pages
779 - 805
Database
ISI
SICI code
1081-0706(2001)17:<779:LADIV>2.0.ZU;2-2
Abstract
A distinctive and essential feature of the vertebrate body is a pronounced left-right asymmetry of internal organs and the central nervous system. Rem arkably, the direction of left-right asymmetry is consistent among all norm al individuals in a species and, for many organs, is also conserved across species, despite the normal health of individuals with mirror-image anatomy . The mechanisms that determine stereotypic left-right asymmetry have fasci nated biologists for over a century. Only recently, however, has our unders tanding of the left-right patterning been pushed forward by links to specif ic genes and proteins. Here we examine the molecular biology of the three p rincipal steps in left-right determination: breaking bilateral symmetry, pr opagation and reinforcement of pattern, and the translation of pattern into asymmetric organ morphogenesis.