The molecular basis of sister-chromatid cohesion

Citation
Jy. Lee et Tl. Orr-weaver, The molecular basis of sister-chromatid cohesion, ANN R C DEV, 17, 2001, pp. 753-777
Citations number
108
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
17
Year of publication
2001
Pages
753 - 777
Database
ISI
SICI code
1081-0706(2001)17:<753:TMBOSC>2.0.ZU;2-Z
Abstract
The replicated copies of each chromosome, the sister chromatids, are attach ed prior to their segregation in mitosis and meiosis. This association or c ohesion is critical for each sister chromatid to bind to microtubules from opposite spindle poles and thus segregate away from each other at anaphase of mitosis or meiosis II. The cohesin protein complex is essential for cohe sion in both mitosis and meiosis, and cleavage of one of the subunits is su fficient for loss of cohesion at anaphase. The localization of the cohesin complex and other cohesion proteins permits evaluation of the positions of sister-chromatid associations within the chromosome structure, as well as t he relationship between cohesion and condensation. Recently, two key riddle s in the mechanism of meiotic chromosome segregation have yielded to molecu lar answers. First, analysis of the cohesin complex in meiosis provides mol ecular support for the long-standing hypothesis that sister-chromatid cohes ion links homologs in meiosis I by stabilizing chiasmata. Second, the isola tion of the monopolin protein that controls kinetochore behavior in meiosis I defines a functional basis by which sister kinetochores are directed tow ard the same pole in meiosis I.