Getting the message across: The intracellular localization of mRNAs in higher eukaryotes

Citation
Im. Palacios et Ds. Johnston, Getting the message across: The intracellular localization of mRNAs in higher eukaryotes, ANN R C DEV, 17, 2001, pp. 569-614
Citations number
281
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
17
Year of publication
2001
Pages
569 - 614
Database
ISI
SICI code
1081-0706(2001)17:<569:GTMATI>2.0.ZU;2-W
Abstract
The intracellular localization of mRNA, a common mechanism for targeting pr oteins to specific regions of the cell, probably occurs in most if not all polarized cell types. Many of the best characterized localized mRNAs are fo und in oocytes and early embryos, where they function as localized determin ants that control axis formation and the development of the germline. Howev er, mRNA localization has also been shown to play an important role in soma tic cells, such as neurons, where it may be involved in learning and memory . mRNAs can be localized by a variety of mechanisms including local protect ion from degradation, diffusion to a localized anchor, and active transport , and we consider the evidence for each of these processes, before discussi ng the cis-acting elements that direct the localization of specific mRNAs a nd the trans-acting factors that bind them.