Embryo-derived stem cells: Of mice and men

Authors
Citation
Ag. Smith, Embryo-derived stem cells: Of mice and men, ANN R C DEV, 17, 2001, pp. 435-462
Citations number
123
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
17
Year of publication
2001
Pages
435 - 462
Database
ISI
SICI code
1081-0706(2001)17:<435:ESCOMA>2.0.ZU;2-D
Abstract
Mouse embryonic stem cells are continuous cell lines derived directly from the fetal founder tissue of the preimplantation. embryo. They can be expand ed in culture while retaining the functional attributes of pluripotent earl y embryo cells. In particular, they can participate fully in fetal developm ent when reintroduced into the embryo. The capacity for multilineage differ entiation is reproduced in culture where embryonic stem cells can produce a wide range of well-defined cell types. This has stimulated interest in the isolation of analogous cells of human origin. Such human pluripotent stem cells could constitute a renewable source of more differentiated cells that could be employed to replace diseased or damaged tissue by cellular transp lantation. In this review, the relationships between mouse embryonic stem c ells, resident pluripotent cells in the embryo, and human embryo-derived ce ll lines are evaluated, and the prospects and challenges of embryo stem cel l research are considered.