Recent advances in chemical approaches to the study of biological systems

Citation
Ma. Shogren-knaak et al., Recent advances in chemical approaches to the study of biological systems, ANN R C DEV, 17, 2001, pp. 405-433
Citations number
112
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
17
Year of publication
2001
Pages
405 - 433
Database
ISI
SICI code
1081-0706(2001)17:<405:RAICAT>2.0.ZU;2-B
Abstract
A number of novel chemical methods for studying biological systems have rec ently been developed that provide a means of addressing biological question s not easily studied with other techniques. In this review, examples that h ighlight the development and use of such chemical approaches are discussed. Specifically, strategies for modulating protein activity or protein-protei n interactions using small molecules are presented. In addition, methods fo r generating and utilizing novel biomolecules (proteins, oligonucleotides, oligosaccharides, and second messengers) are examined.