A number of novel chemical methods for studying biological systems have rec
ently been developed that provide a means of addressing biological question
s not easily studied with other techniques. In this review, examples that h
ighlight the development and use of such chemical approaches are discussed.
Specifically, strategies for modulating protein activity or protein-protei
n interactions using small molecules are presented. In addition, methods fo
r generating and utilizing novel biomolecules (proteins, oligonucleotides,
oligosaccharides, and second messengers) are examined.