Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations

Citation
Il. Weissman et al., Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations, ANN R C DEV, 17, 2001, pp. 387-403
Citations number
99
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
17
Year of publication
2001
Pages
387 - 403
Database
ISI
SICI code
1081-0706(2001)17:<387:SAPCOP>2.0.ZU;2-D
Abstract
Multipotent stem cells are clonal cells that self-renew as well as differen tiate to regenerate adult tissues. Whereas stem cells and their fates are k nown by unique genetic marker Studies, the fate and function of these cells are best studied by their prospective isolation. This review is about the properties of various highly purified tissue-specific multipotent stem cell s and purified oligolineage progenitors. We contend that unless the stem or progenitor cells in question have been purified to near homogeneity, one c annot know whether their generation of expected (or unexpected) progeny is a property of a known cell type. It is interesting that in the hematopoieti c system the only long-term self-renewing cells in the stem and progenitors pool are the hematopoietic stem cells. This fact is discussed in the conte xt of normal and leukemic hematopoiesis.