Animal cell cytokinesis

Authors
Citation
M. Glotzer, Animal cell cytokinesis, ANN R C DEV, 17, 2001, pp. 351-386
Citations number
192
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
17
Year of publication
2001
Pages
351 - 386
Database
ISI
SICI code
1081-0706(2001)17:<351:ACC>2.0.ZU;2-0
Abstract
Cytokinesis creates two daughter cells endowed with a complete set of chrom osomes and cytoplasmic organelles. This conceptually simple event is mediat ed by a complex and dynamic interplay between the microtubules of the mitot ic spindle, the actomyosin cytoskeleton, and membrane fusion events. For ma ny decades the study of cytokinesis was driven by morphological studies on specimens amenable to physical manipulation. The studies led to great insig hts into the cellular structures that orchestrate cell division, but the un derlying molecular machinery was largely unknown. Molecular and genetic app roaches have now allowed the initial steps in the development of a molecula r understanding of this fundamental event in the life of a cell, This revie w provides an overview of the literature on cytokinesis with a particular e mphasis on the molecular pathways involved in the division of animal cells.