Early eye development in vertebrates

Authors
Citation
Rl. Chow et Ra. Lang, Early eye development in vertebrates, ANN R C DEV, 17, 2001, pp. 255-296
Citations number
250
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
17
Year of publication
2001
Pages
255 - 296
Database
ISI
SICI code
1081-0706(2001)17:<255:EEDIV>2.0.ZU;2-B
Abstract
This review provides a synthesis that combines data from classical experime ntation and recent advances in our understanding of early eye development. Emphasis is placed on the events that underlie and direct neural retina for mation and lens induction. Understanding these events represents a longstan ding problem in developmental biology. Early interest can be attributed to the curiosity generated by the relatively frequent occurrence of disorders such as cyclopia and anophthalmia, in which dramatic changes in eye develop ment are readily observed. However, it was the advent of experimental embry ology at the turn of the century that transformed curiosity into active inv estigation. Pioneered by investigators such as Spemann and Adelmann, these embryological manipulations have left a profound legacy. Questions about ea rly eye development first addressed using tissue manipulations remain topic al as we try to understand the molecular basis of this process.