Molecular bases of circadian rhythms

Citation
Sl. Harmer et al., Molecular bases of circadian rhythms, ANN R C DEV, 17, 2001, pp. 215-253
Citations number
250
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
17
Year of publication
2001
Pages
215 - 253
Database
ISI
SICI code
1081-0706(2001)17:<215:MBOCR>2.0.ZU;2-G
Abstract
Circadian rhythms are found inmost eukaryotes and some prokaryotes. The mec hanism by which organisms maintain these roughly 24-h rhythms in the absenc e of environmental stimuli has long been a mystery and has recently been th e subject of intense research. In the past few years, we have seen explosiv e progress in the understanding of the molecular basis of circadian rhythms in model systems ranging from cyanobacteria to mammals. This review attemp ts to outline these primarily genetic and biochemical findings and encompas ses work done in cyanobacteria, Neurospora, higher plants, Drosophila, and rodents, Although actual clock components do not seem to be conserved betwe en kingdoms, central clock mechanisms are conserved. Somewhat paradoxically , clock components that are conserved between species can be used in divers e ways. The different uses of common components may reflect the important r ole that the circadian clock plays in adaptation of species to particular e nvironmental niches.