Boundaries in development: Formation and function

Citation
Kd. Irvine et C. Rauskolb, Boundaries in development: Formation and function, ANN R C DEV, 17, 2001, pp. 189-214
Citations number
130
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
17
Year of publication
2001
Pages
189 - 214
Database
ISI
SICI code
1081-0706(2001)17:<189:BIDFAF>2.0.ZU;2-G
Abstract
Developing organisms may contain billions of cells destined to differentiat e in numerous different ways. One strategy organisms use to simplify the or chestration of development is the separation of cell populations into disti nct functional units. Our expanding knowledge of boundary formation and fun ction in different systems is beginning to reveal general principles of thi s process. Fields of cells are subdivided by the interpretation of morphoge n gradients, and these subdivisions are then maintained and refined by loca l cell-cell interactions. Sharp and stable separation between cell populati ons requires special mechanisms to keep cells segregated, which in many cas es appear to involve the regulation of cell affinity. Once cell populations become distinct, specialized cells are often induced along the borders bet ween them. These boundary cells can then influence the patterning of surrou nding cells, which can result in progressively finer subdivisions of a tiss ue. Much has been learned about the signaling pathways that establish bound aries, but a key challenge for the future remains to elucidate the cellular and molecular mechanisms that actually keep cell populations separated.