Chemical and biological strategies for engineering cell surface glycosylation

Citation
E. Saxon et Cr. Bertozzi, Chemical and biological strategies for engineering cell surface glycosylation, ANN R C DEV, 17, 2001, pp. 1-23
Citations number
91
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
ISSN journal
1081-0706 → ACNP
Volume
17
Year of publication
2001
Pages
1 - 23
Database
ISI
SICI code
1081-0706(2001)17:<1:CABSFE>2.0.ZU;2-X
Abstract
Oligosaccharides play a crucial role in many of the recognition, signaling, and adhesion events that take place at the surface of cells. Abnormalities in the synthesis or presentation of these carbohydrates can lead to misfol ded and inactive proteins, as well as to several debilitating disease state s. However, their diverse structures, which are the key to their function, have hampered studies by biologists and chemists alike. This review present s an overview of techniques for examining and manipulating cell surface oli gosaccharides through genetic, enzymatic, and chemical strategies.