Clinical significance of neuroendocrine phenotype in non-small-cell lung cancer

Citation
C. Carnaghi et al., Clinical significance of neuroendocrine phenotype in non-small-cell lung cancer, ANN ONCOL, 12, 2001, pp. S119-S123
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
ANNALS OF ONCOLOGY
ISSN journal
0923-7534 → ACNP
Volume
12
Year of publication
2001
Supplement
2
Pages
S119 - S123
Database
ISI
SICI code
0923-7534(2001)12:<S119:CSONPI>2.0.ZU;2-I
Abstract
Non-small-cell lung carcinoma (NSCLC) describes a histologically heterogene ous group of tumours with variable clinical behaviour. Performance status, tumour stage and histological type have important prognostic implications, but clinical outcomes in individual patients remain unpredictable. A signif icant minority of NSCLCs (10%-30%) show neuroendocrine (NE) differentiation , and a number of studies have attempted to evaluate the therapeutic and pr ognostic significance of the expression of NE markers on the basis of the t heoretical assumption that NE-differentiated tumours may be associated with an adverse prognosis and greater chemosensitivity, However, the results of these studies are conflicting: some have found that NE differentiation has a negative impact on survival, but others have failed to demonstrate any c orrelation with prognosis. Similar discrepancies have also been observed in terms of chemosensitivity. Nevertheless, these data are difficult to inter pret because there is no gold standard defining NE differentiation, as is s hown by the fact that the proportion of NE-differentiated NSCLCs varies acc ording to the technique and marker used, although chromogranin A and synapt ophysin show the best correlation with ultrastructural evidence of NE diffe rentiation. In conclusion, there is no doubt that caution is required when interpreting the results of a number of studies questioning the clinical im pact of the NE features of NSCLCs.