The effects of increasing concentrations of isoflurane and desflurane on pulmonary perfusion and systemic oxygenation during one-lung ventilation in pigs

Citation
K. Schwarzkopf et al., The effects of increasing concentrations of isoflurane and desflurane on pulmonary perfusion and systemic oxygenation during one-lung ventilation in pigs, ANESTH ANAL, 93(6), 2001, pp. 1434-1438
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
ANESTHESIA AND ANALGESIA
ISSN journal
0003-2999 → ACNP
Volume
93
Issue
6
Year of publication
2001
Pages
1434 - 1438
Database
ISI
SICI code
0003-2999(200112)93:6<1434:TEOICO>2.0.ZU;2-R
Abstract
During one-lung ventilation (OLV), hypoxic pulmonary vasoconstriction (HPV) reduces venous admixture and attenuates the decrease in arterial oxygen te nsion by diverting blood from the nonventilated lung to the ventilated lung . In vitro, desflurane and isoflurane depress HPV in a dose-dependent manne r. Accordingly, we studied the effects of increasing concentrations of desf lurane and isoflurane on pulmonary perfusion, shunt fraction, and PaO2 duri ng OLV in vivo. Fourteen pigs (30 - 42 kg) were anesthetized, tracheally in tubated, and mechanically ventilated. After placement of femoral arterial a nd thermodilution pulmonary artery catheters, a left-sided double-lumen tub e (DLT) was placed via tracheotomy. After DLT placement, FIO2 was adjusted at 0.8 and anesthesia was continued in random order with 3 concentrations ( 0.5, 1.0, and 1.5 minimal alveolar concentrations) of either desflurane or isoflurane. Differential lung perfusion was measured with colored microsphe res. All measurements were made after stabilization at each concentration. Whereas mixed venous PO2, mean arterial pressure, cardiac output, nonventil ated lung perfusion, and shunt fraction decreased in a dose-dependent manne r, PaO2 remained unchanged with increasing concentrations of desflurane and isoflurane during OLV. In conclusion, increasing concentration of desflura ne and isoflurane did not impair oxygenation during OLV in pigs.