Burkholderia cepacia complex genomovars and pulmonary transplantation outcomes in patients with cystic fibrosis

Citation
A. De Soyza et al., Burkholderia cepacia complex genomovars and pulmonary transplantation outcomes in patients with cystic fibrosis, LANCET, 358(9295), 2001, pp. 1780-1781
Citations number
5
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
0140-6736 → ACNP
Volume
358
Issue
9295
Year of publication
2001
Pages
1780 - 1781
Database
ISI
SICI code
0140-6736(20011124)358:9295<1780:BCCGAP>2.0.ZU;2-P
Abstract
Burkholderia cepacia is a group of organisms that comprises seven genotypic ally distinct species (B cepacia genomovars I-VII), which are collectively known as the B cepacia complex. Preoperative infection with B cepacia Is as sociated with a poor prognosis in lung transplant recipients with cystic fi brosis. Many centres do not, therefore, offer transplants to these Individu als. Our aim was to ascertain whether or not post-transplant mortality is a ffected by pretransplant genomovar status. We studied archived isolates wit h PCR-based methods, and recorded excessive mortality in patients infected with B cepacia genomovar III, but not in those infected with other genomova rs.