A mathematical model of electron transfer within the mitochondrial respiratory cytochromes

Citation
Ad. Farmery et Jp. Whiteley, A mathematical model of electron transfer within the mitochondrial respiratory cytochromes, J THEOR BIO, 213(2), 2001, pp. 197-207
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary
Journal title
JOURNAL OF THEORETICAL BIOLOGY
ISSN journal
0022-5193 → ACNP
Volume
213
Issue
2
Year of publication
2001
Pages
197 - 207
Database
ISI
SICI code
0022-5193(20011121)213:2<197:AMMOET>2.0.ZU;2-W
Abstract
A simple mathematical model of electron flow along the mitochondrial respir atory cytochrome assembly and the transfer of electrons to molecular oxygen is presented. First, an expression for the current-voltage relationship fo r a biological oxygen electrode is derived, and from this the relationship between oxygen consumption rate and oxygen partial pressure is determined. An independent relationship between mitochondrial oxygen partial pressure a nd oxygen supply rate is then derived. By eliminating oxygen partial pressu re from these two expressions, we may obtain a relationship between oxygen supply rate and oxygen consumption rate. This model is then used to investi gate the effects of tissue dysoxia, uncoupling of oxidative phosphorylation , increased cellular diffusional resistance and inhomogeneities in oxygen s upply on oxygen consumption. It is concluded that each of the above contrib ute in varying degrees to the phenomenon of "pathological oxygen supply dep endency". (C) 2001 Academic Press.