A cellular oscillator model for periodic pattern formation

Citation
J. Jaeger et Bc. Goodwin, A cellular oscillator model for periodic pattern formation, J THEOR BIO, 213(2), 2001, pp. 171-181
Citations number
45
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary
Journal title
JOURNAL OF THEORETICAL BIOLOGY
ISSN journal
0022-5193 → ACNP
Volume
213
Issue
2
Year of publication
2001
Pages
171 - 181
Database
ISI
SICI code
0022-5193(20011121)213:2<171:ACOMFP>2.0.ZU;2-F
Abstract
In this paper, we present a model for pattern formation in developing organ isms that is based on cellular oscillators (CO). An oscillatory process wit hin cells serves as a developmental clock whose period is tightly regulated by cell autonomous or non-autonomous mechanisms. A spatial pattern is gene rated as a result of an initial temporal ordering of the cell oscillators f reezing into spatial order as the clocks slow down and stop at different ti mes or phases in their cycles. We apply a CO model to vertebrate somitogene sis and show that we can reproduce the dynamics of periodic gene expression patterns observed in the pre-somitic mesoderm. We also show how varying so mite lengths can be generated with the CO model. We then discuss the model in view of experimental evidence and its relevance to other instances of bi ological pattern formation, showing its versatility as a pattern generator. (C) 2001 Academic Press.