Protective effects of Panax ginseng on muscle injury and inflammation after eccentric exercise

Citation
Acc. De Oliveira et al., Protective effects of Panax ginseng on muscle injury and inflammation after eccentric exercise, COMP BIOC C, 130(3), 2001, pp. 369-377
Citations number
34
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
ISSN journal
1532-0456 → ACNP
Volume
130
Issue
3
Year of publication
2001
Pages
369 - 377
Database
ISI
SICI code
1532-0456(200111)130:3<369:PEOPGO>2.0.ZU;2-1
Abstract
Eccentric muscle contraction causes fibre injury associated with disruption of the myofibrillar cytoskeleton. The medicinal plant Panax ginseng C.A. M eyer, known for its therapeutic properties, was studied to explore its prot ective effects after eccentric contraction. A crude extract and a standardi sed extract (G115) of different saponin compositions were tested as to thei r efficacy in reducing lipid peroxidation, inflammation and release of myoc ellular proteins after the realisation of an eccentric contraction protocol on a rat treadmill. Plasma creatine kinase (CK) levels were significantly reduced by approximately 25% after ingestion of both extracts of ginseng. B oth extracts reduced lipid peroxidation by approximately 15% as measured by malondialdehyde levels. P-Glucuronidase concentrations and glucose-6-phosp hate dehydrogenase (G6PDH) levels, which can be considered markers of infla mmation, were also significantly reduced. The values of P-glucuronidase wer e increased from 35.9 +/- 1.5 to 128.4 +/- 8.1 in vastus and to 131.1 +/- 1 2.1 U g(-1) in rectus, the protection due to ginseng administration being a pproximately 40% in both muscles. Both extracts appeared to be equally effe ctive in reducing injuries and inflammation caused by eccentric muscle cont ractions. (C) 2001 Elsevier Science Inc. All rights reserved.