Expression of the MTA1 mRNA in thymoma patients

Sasaki, H Yukiue, H Kobayashi, Y Nakashima, Y Kaji, M Fukai, I Kiriyama, M Yamakawa, Y Fujii, Y

H. Sasaki et al., Expression of the MTA1 mRNA in thymoma patients, CANCER LETT, 174(2), 2001, pp. 159-163

22

INGLESE

Article

Onconogenesis & Cancer Research

CANCER LETTERS

0304-3835 → ACNP

174

2

2001

159 - 163

ISI

0304-3835(200112)174:2<159:EOTMMI>2.0.ZU;2-Q

The MTA1 gene is a recently identified metastasis-associated gene which has been implicated in the signal transduction or regulation of gene expressio n. We examined the mRNA expression levels of the MTA1, the human homologue of the rat mtal gene in thymoma. Expression of MTA1 mRNA was evaluated by r everse transcription polymerase chain reaction (RT-PCR) in 30 thymoma. samp les using LightCycler. The data was analyzed in reference to clinicopatholo gical data. There was no relationship between MTA1 gene expression and age and gender. MTA1/GAPDH mRNA level in stage IV thymoma. (6.431 +/- 3.404) wa s significantly higher than the level in stage I thymoma (2.592 +/- 1.902, P = 0.0081). There was a tendency towards higher MTA1/GAPDH mRNA level in s tage IV thymoma. when compared to stage II thymoma (3.746 +/- 3.292, P = 0. 072). Thus our results show that the expression of the MTA1 gene is closely related to invasiveness in thymoma. The gene MTA1 could potentially provid e information on the mechanism of tumor invasion and metastasis. (C) 2001 E lsevier Science Ireland Ltd. All rights reserved.