The MTA1 gene is a recently identified metastasis-associated gene which has
been implicated in the signal transduction or regulation of gene expressio
n. We examined the mRNA expression levels of the MTA1, the human homologue
of the rat mtal gene in thymoma. Expression of MTA1 mRNA was evaluated by r
everse transcription polymerase chain reaction (RT-PCR) in 30 thymoma. samp
les using LightCycler. The data was analyzed in reference to clinicopatholo
gical data. There was no relationship between MTA1 gene expression and age
and gender. MTA1/GAPDH mRNA level in stage IV thymoma. (6.431 +/- 3.404) wa
s significantly higher than the level in stage I thymoma (2.592 +/- 1.902,
P = 0.0081). There was a tendency towards higher MTA1/GAPDH mRNA level in s
tage IV thymoma. when compared to stage II thymoma (3.746 +/- 3.292, P = 0.
072). Thus our results show that the expression of the MTA1 gene is closely
related to invasiveness in thymoma. The gene MTA1 could potentially provid
e information on the mechanism of tumor invasion and metastasis. (C) 2001 E
lsevier Science Ireland Ltd. All rights reserved.