Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants

Itoigawa, M Ito, C Tan, HTW Okuda, M Tokuda, H Nishino, H Furukawa, H

M. Itoigawa et al., Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants, CANCER LETT, 174(2), 2001, pp. 135-139

7

INGLESE

Article

Onconogenesis & Cancer Research

CANCER LETTERS

0304-3835 → ACNP

174

2

2001

135 - 139

ISI

0304-3835(200112)174:2<135:CCAONA>2.0.ZU;2-#

As a part of screening studies for cancer chemopreventive agents (anti-tumo r promoters), six natural and four synthetic naphthoquinones and five of th eir analogs were tested for their inhibitory activities against Epstein-Bar r virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-ac etate in Raji cells. Some of the 1,4-naphthoquinones and their analogs were found to show remarkably potent activities, without showing any cytotoxici ty. 1,4-Furanonaphthoquinone (5) and its analog (9) isolated from Avicennia plants (Avicenniaceae), having an alcoholic OH group on the dihydrofuran-r ing, displayed the mo st potent activity. Furthermore, avicenol-A (9) exhib ited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The result of the present investigation ind icated that some of these 1,4-naphthoquinones and their analogs might be va luable as potent cancer chemopreventive agents. (C) 2001 Elsevier Science I reland Ltd. All rights reserved.