Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants

Citation
M. Itoigawa et al., Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants, CANCER LETT, 174(2), 2001, pp. 135-139
Citations number
7
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
0304-3835 → ACNP
Volume
174
Issue
2
Year of publication
2001
Pages
135 - 139
Database
ISI
SICI code
0304-3835(200112)174:2<135:CCAONA>2.0.ZU;2-#
Abstract
As a part of screening studies for cancer chemopreventive agents (anti-tumo r promoters), six natural and four synthetic naphthoquinones and five of th eir analogs were tested for their inhibitory activities against Epstein-Bar r virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-ac etate in Raji cells. Some of the 1,4-naphthoquinones and their analogs were found to show remarkably potent activities, without showing any cytotoxici ty. 1,4-Furanonaphthoquinone (5) and its analog (9) isolated from Avicennia plants (Avicenniaceae), having an alcoholic OH group on the dihydrofuran-r ing, displayed the mo st potent activity. Furthermore, avicenol-A (9) exhib ited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The result of the present investigation ind icated that some of these 1,4-naphthoquinones and their analogs might be va luable as potent cancer chemopreventive agents. (C) 2001 Elsevier Science I reland Ltd. All rights reserved.