A series of benzo(b)thiophenesulfonamide 1,1-dioxide derivatives (13TS) hav
e been designed and synthesized as candidate antineoplastic drugs. Several
of these compounds have shown in vitro cytotoxic activity on leukaemic CCRF
-CEM cells. The cytotoxic BTS, but not the inactive ones, were able to inhi
bit a tumour cell-specific NADH oxidase activity present in the membrane of
CCRF-CEM cells. (C) 2001 Cancer Research Campaign.