AVP (4-8) improves concept learning in PFC-damaged but not hippocampal-damaged rats

Citation
A. Dietrich et al., AVP (4-8) improves concept learning in PFC-damaged but not hippocampal-damaged rats, BRAIN RES, 919(1), 2001, pp. 41-47
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
0006-8993 → ACNP
Volume
919
Issue
1
Year of publication
2001
Pages
41 - 47
Database
ISI
SICI code
0006-8993(20011116)919:1<41:A(ICLI>2.0.ZU;2-4
Abstract
A position reversal task was used to test the memory-enhancing effects of t he arginine vasopressin analog [pGlu4, Cyt6] AVP (4-8) at a dose of 1.5 mug /kg Rats received either sham operations (SHM), medial prefrontal cortex le sions (PFC), or hippocampal lesions (HIP). The peptide was administered dai ly, via s.c. injection, 30 min prior to training to half of the animals in each group. As expected, all animals performed equally well on the initial position habit and the first reversal. Overall, it was found that AVP (4-8) -treated animals performed significantly better across trials than saline ( SAL)-treated animals. Further analysis showed that PFC animals that receive d AVP (4-8) (PFC+AVP) performed significantly better (at the level of contr ols) across trials than saline-treated PFC (PFC+SAL) animals. Sham animals that received the AVP (4-8) analog (SHM+AVP) only showed significant improv ement on the last two reversals when compared to the sham saline-treated an imals (SHM+SAL), which was likely due to a ceiling effect as performance re ached high levels early in the reversal task. Trial 2 analysis across rever sals revealed enhanced cognitive abilities in both sham groups (SHM+SAL, SH M+AVP) and the PFC+AVP group, but not in the PFC+SAL, HIP+AVP or the HIP+SA L groups. Hippocampal lesioned animals performed poorly on the task and inj ections of AVP (4-8) did not improve their performance. It is thus conclude d that AVP (4-8) enhanced the acquisition of concept learning (win-stay/loo se-shift) in this paradigm in PFC-damaged animals and ameliorated the perse verance habit that is often seen in PFC animals on this task. It is suggest ed that AVP (4-8) might have an enhancing effect on general cognitive abili ties that is not limited to memory processes. (C) 2001 Elsevier Science BY All rights reserved.