T. Kobayashi et al., Semi-continuous production of lauroyl kojic acid through lipase-catalyzed condensation in acetonitrile, BIOCH ENG J, 9(2), 2001, pp. 85-89
7-O-Lauroyl kojic acid was synthesized on some tens of grams scale through
lipase-catalyzed condensation of kojic and lauric acids in acetonitrile usi
ng a semi-continuous system where unreacted substrates were reused after th
e product recovery. The acylation of kojic acid improved the solubility in
hexane and soybean oil. The absorption spectra of lauroyl kojic acid chelat
ed with ferric ion were observed in ethanol and soybean oil at various mola
r ratios. The color tone of the complex of lauroyl kojic acid and Fe3+ was
similar to that of the complex of unmodified kojic acid and Fe3+ in ethanol
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