Cytologic features of desmoplastic infantile ganglioglioma - A report of two cases

Citation
Y. Hasegawa et al., Cytologic features of desmoplastic infantile ganglioglioma - A report of two cases, ACT CYTOL, 45(6), 2001, pp. 1037-1042
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
ACTA CYTOLOGICA
ISSN journal
0001-5547 → ACNP
Volume
45
Issue
6
Year of publication
2001
Pages
1037 - 1042
Database
ISI
SICI code
0001-5547(200111/12)45:6<1037:CFODIG>2.0.ZU;2-P
Abstract
BACKGROUND: Desmoplastic infantile ganglioglioma (DIG) is a rare intracrani al tumor of infancy, characterized by solid and cystic components, volumino us size and supratentorial location. Although its histologic features have been reported, there has been no cytologic description of the tumor. Cytolo gic findings on imprint and aspirated material from two cases of histologic ally verified DIG are discussed. CASES: A 12-month-old male with cutis marmorata telangiectatica congenita a nd a 44-month-old female with episodes of spasm were referred to our center . Radiologic examination revealed a large, cystic, supratentorial mass in b oth patients. The mass was surgically removed, and histology revealed promi nent desmoplasia with a mixture of astroglial and neuronal cells. Cytologic findings on imprint material and the needle aspirates taken from the cysti c area of the tumor revealed a few isolated or sheetlike arrangements of sm all cells positive for glial fibrillary acidic protein and a few large cell s with abundant cytoplasm and prominent nucleoli, positive for neuronal mar ker. CONCLUSION. Although distinction between ganglio-glioma and DIG may be diff icult by cytology alone, with the characteristic clinical presentation and radiologic findings, the possibility of DIG should be kept in mind when the specimens contain both astroglial and neuronal elements.