Changes in plasma antiproteases in paraquat poisoned rats using micro two-dimensional electrophoretic analysis

Citation
K. Kageyama et al., Changes in plasma antiproteases in paraquat poisoned rats using micro two-dimensional electrophoretic analysis, VET HUM TOX, 43(6), 2001, pp. 321-326
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
VETERINARY AND HUMAN TOXICOLOGY
ISSN journal
0145-6296 → ACNP
Volume
43
Issue
6
Year of publication
2001
Pages
321 - 326
Database
ISI
SICI code
0145-6296(200112)43:6<321:CIPAIP>2.0.ZU;2-T
Abstract
Rats were subjected to subacute paraoquat (PQ) exposure (7 mg/kg sc claim f or 6-9 administrations). They were divided into a group that died from suba cute toxicity, a group that recovered from the subacute toxicity and progre ssed to pulmonary fibrosis, and a group that showed no effects from the PQ. The rats with subacute fatal toxicity had a remarkable increase in a(2)M-I . Those which progressed to pulmonary fibrosis had remarkable decreases in a(2)M-2, a2M-3, and a(2)M-4 and a(1)AT. The rats that showed no effects fro m the PQ had relative increases in all molecular species of a(2)M. Increase s in major a(2)M molecular species,a(2)M-I and a(2)M-4, and a minor molecul ar species,a(2)M-3, were characteristically observed.