The HELLP syndrome, a prospective study

Citation
Ka. Abraham et al., The HELLP syndrome, a prospective study, RENAL FAIL, 23(5), 2001, pp. 705-713
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology
Journal title
RENAL FAILURE
ISSN journal
0886-022X → ACNP
Volume
23
Issue
5
Year of publication
2001
Pages
705 - 713
Database
ISI
SICI code
0886-022X(2001)23:5<705:THSAPS>2.0.ZU;2-T
Abstract
We undertook this study to evaluate the incidence and outcome of HELLP in I rish patients. In addition, duration and trends of the abnormal laboratory results were studied. Study Design. This prospective observational study sc reened 12068 pregnant women between January 1995 and March 1997. Any pregna nt woman with hypertension, proteinuria, thrombocytopenia or anemia was mon itored for hemolysis and elevated liver transaminases, from the time of rec ruitment till six weeks postpartum or resolution. Results. Thirteen of 1206 8 pregnant women (0.11%) developed HELLP. All had hypertension and 84.6% ha d proteinuria. Delivery was the only factor found to terminate the syndrome . Acute renal dysfunction was noted in 53.8% but none required dialysis. La boratory parameters stabilized by the sixth postpartum day. Fetal mortality was 1 out of 14. There were no maternal deaths. Conclusions. HELLP syndrom e is a rare but potentially serious complication of pregnancy. Correlation with laboratory data and early intervention are vital in achieving a favora ble outcome for both mother and fetus.