Protein folding cooperativity in the correlated lattice

Authors
Citation
A. Fernandez, Protein folding cooperativity in the correlated lattice, PHYS LETT A, 290(1-2), 2001, pp. 101-105
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physics
Journal title
PHYSICS LETTERS A
ISSN journal
0375-9601 → ACNP
Volume
290
Issue
1-2
Year of publication
2001
Pages
101 - 105
Database
ISI
SICI code
0375-9601(20011105)290:1-2<101:PFCITC>2.0.ZU;2-J
Abstract
As it folds onto itself under in vitro renaturation conditions, a protein c reates local solvent environments which affect its pairwise intramolecular interactions. This context dependence of the folding process is modelled by introducing spatially correlated self-avoiding walks in a cubic lattice. I n contrast with the context-insensitive chain, the energy spectrum for the spatially correlated walker is shown to be highly localized, forming a few clusters of kinetically related states. Furthermore, the spatial correlatio ns are shown to account for the cooperativity of the folding process. (C) 2 001 Elsevier Science B.V. All rights reserved.