Ostia, the inflow tracts of the Drosophila heart, develop from a genetically distinct subset of cardial cells

Citation
Mr. Molina et Rm. Cripps, Ostia, the inflow tracts of the Drosophila heart, develop from a genetically distinct subset of cardial cells, MECH DEVEL, 109(1), 2001, pp. 51-59
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
MECHANISMS OF DEVELOPMENT
ISSN journal
0925-4773 → ACNP
Volume
109
Issue
1
Year of publication
2001
Pages
51 - 59
Database
ISI
SICI code
0925-4773(200111)109:1<51:OTITOT>2.0.ZU;2-X
Abstract
The homeobox gene tinmun and the nuclear receptor gene seven-up are express ed in mutually exclusive dorsal vessel cells in Drosophila, however, the ph ysiological reason for this distinction is not known. We demonstrate that t in and svp-lacZ expression persists through the larval stage to the adult s tage in the same pattern of cells expressing these genes in the embryo. In the larva, six pairs of Svp-expressing cells form muscular ostia. which per mit hemolymph to enter the heart for circulation, however, more anterior Sv p-expressing cells form the wall of the dorsal vessel. During pupation, the adult heart forms from a chimera of larval and imaginal muscle fibers. The portion of the dorsal vessel containing the larval ostia is histolyzed and the anterior Svp-expressing cells metamorphose into imaginal ostia. This i s the first demonstration that the significant molecular diversity of cardi al cells identified in the embryonic heart correlates with the formation of physiologically and functionally distinct muscle cells in the animal. Furt hermore, our experiments define the cellular changes that occur as the larv al heart is remodeled into an imaginal structure in an important model orga nism. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.