Aldol-type condensation reactions of alpha -monosubstituted selenoamides wi
th a variety of aldehydes are examined to furnish beta -hydroxy selenoamide
s in good to high yields. The use of selenoamides derived from dibenzylamin
e exhibits high stereoselectivity. As for the reaction with aliphatic aldeh
ydes selenoamides show better yields and selectivity compared with ordinary
amides. Conversion of the resulting beta -hydroxy selenoamides to 1,3-amin
o alcohols is also described.