Post-transplant malignant lymphoma with monoclonal immunoglobulin gene rearrangement and polyclonal Epstein-Barr virus episomes

Citation
Y. Sadahira et al., Post-transplant malignant lymphoma with monoclonal immunoglobulin gene rearrangement and polyclonal Epstein-Barr virus episomes, J CLIN PATH, 54(11), 2001, pp. 887-889
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF CLINICAL PATHOLOGY
ISSN journal
0021-9746 → ACNP
Volume
54
Issue
11
Year of publication
2001
Pages
887 - 889
Database
ISI
SICI code
0021-9746(200111)54:11<887:PMLWMI>2.0.ZU;2-L
Abstract
This report describes the case of an 8 year old boy who developed ileocecal B cell lymphoma after liver transplantation. The patient underwent orthotr opic liver transplantation for biliary atresia and had been given immunosup pressive drugs-cyclosporin A and tacrolimus hydrate. Six years after the li ver transplantation, the patient had a sudden onset of fever and abdominal pain. Necropsy revealed an ileocecal mass that was a B cell lymphoma. Epste in-Barr virus (EBV) encoded RNA I was demonstrated in lymphoma cells and hy perplastic follicular germinal centre cells in various tissues. Although mo noclonal immunoglobulin gene rearrangement was detected in the liver, EBV e pisomes were of polyclonal origin and lytic forms of EBV were also demonstr ated by Southern blotting. lmmunohistochemically, lymphoma cells were posit ive for p53 but negative for latent membrane protein 1 and EBV nuclear anti gen 2. These findings suggested that this B cell lymphoma might have occurr ed sporadically, regardless of EBV infection.