Association between serum leptin concentrations and bone mineral density, and biochemical markers of bone turnover in adult men

Citation
M. Sato et al., Association between serum leptin concentrations and bone mineral density, and biochemical markers of bone turnover in adult men, J CLIN END, 86(11), 2001, pp. 5273-5276
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrynology, Metabolism & Nutrition","Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
ISSN journal
0021-972X → ACNP
Volume
86
Issue
11
Year of publication
2001
Pages
5273 - 5276
Database
ISI
SICI code
0021-972X(200111)86:11<5273:ABSLCA>2.0.ZU;2-L
Abstract
Leptin, the product of the ob gene, has been shown to inhibit bone formatio n in mice. We addressed whether leptin has any role in the regulation of bo ne mineral density (BMD) in humans. Subjects were 221 adult men with a mean ( so) age and body mass index of 52.1 +/- 8.7 yr and 23.6 +/- 2.8 kg/m(2). Serum leptin, carboxyterminal propeptide of type 1 procollagen (PICP; a ma rker of bone formation), and cross-linked carboxyterminal teleopeptide of t ype 1 collagen (a marker of bone resorption) were measured by RIA. BMD was assessed by single photon absorptiometry; and total fat mass was determined by bioimpedance analysis. BMD was inversely associated with serum leptin c oncentrations and total fat mass after adjustment for body weight. PICP, bu t not cross-linked carboxyterminal teleopeptide of type 1 collagen, was inv ersely correlated with serum leptin. These results may suggest that an incr ease in serum leptin reduces bone formation and decreases BMD in adult men. Leptin may be a regulator of BMD in humans.