Changes in the number of gut mucosal T-lymphocytes and macrophages in patients treated by external biliary drainage

Citation
K. Fukuoka et al., Changes in the number of gut mucosal T-lymphocytes and macrophages in patients treated by external biliary drainage, EURO J SURG, 167(9), 2001, pp. 684-688
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery
Journal title
EUROPEAN JOURNAL OF SURGERY
ISSN journal
1102-4151 → ACNP
Volume
167
Issue
9
Year of publication
2001
Pages
684 - 688
Database
ISI
SICI code
1102-4151(200109)167:9<684:CITNOG>2.0.ZU;2-L
Abstract
Objective: To examine the changes in the number of T cells and macrophages in the mucosal lamina propria in the presence or absence of bile in the gas trointestinal tract. Design: Clinical study. Setting: University hospital, Japan. Subjects: 6 patients with obstructive jaundice who had external biliary drainage (drainage group) and 6 patients with no signs of obstructive jaundice (control group). Interventions: Gastrointestinal specimens were taken at the time of operati on. Main outcome Measures: The number of CD4(+) T cells, CD8(+) T cells and CD6 8(+) macrophages in the lamina propria mucosae in each group measured immun ohistochemically. Results: The numbers of CD8+ T cells and CD68(+) macrophages in the lamina propria of the patients treated by external drainage were significantly les s than in the control group (p < 0.01). However, there was no difference in the number of CD4+ T cells between the groups (p = 0.45). Conclusions: In the absence of bile, mucosal immune function fails as a res ult of reduced numbers of CD8+ T cells and macrophages.