Objective: To examine the changes in the number of T cells and macrophages
in the mucosal lamina propria in the presence or absence of bile in the gas
Design: Clinical study.
Setting: University hospital, Japan. Subjects: 6 patients with obstructive
jaundice who had external biliary drainage (drainage group) and 6 patients
with no signs of obstructive jaundice (control group).
Interventions: Gastrointestinal specimens were taken at the time of operati
Main outcome Measures: The number of CD4(+) T cells, CD8(+) T cells and CD6
8(+) macrophages in the lamina propria mucosae in each group measured immun
Results: The numbers of CD8+ T cells and CD68(+) macrophages in the lamina
propria of the patients treated by external drainage were significantly les
s than in the control group (p < 0.01). However, there was no difference in
the number of CD4+ T cells between the groups (p = 0.45).
Conclusions: In the absence of bile, mucosal immune function fails as a res
ult of reduced numbers of CD8+ T cells and macrophages.