In order to understand the mechanism(s) of the resistance/reduced susceptib
ility of Staphylococcus aureus to glycopeptide antibiotics, the current dat
a on the modes of action of glycopeptides were reviewed. In addition, the d
ifferent test systems for detecting vancomycin resistance and the clinical
relevance of resistant Staphylococcus aureus were analyzed. Finally, strate
gies to prevent the nosocomial spread of these bacteria are presented, as a
re new therapeutic options.