Lack of promotion of 7,12-dimethylbenz[a]anthracene-initiated mouse skin carcinogenesis by 1.5 GHz electromagnetic near fields

Citation
K. Imaida et al., Lack of promotion of 7,12-dimethylbenz[a]anthracene-initiated mouse skin carcinogenesis by 1.5 GHz electromagnetic near fields, CARCINOGENE, 22(11), 2001, pp. 1837-1841
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CARCINOGENESIS
ISSN journal
0143-3334 → ACNP
Volume
22
Issue
11
Year of publication
2001
Pages
1837 - 1841
Database
ISI
SICI code
0143-3334(200111)22:11<1837:LOPO7M>2.0.ZU;2-7
Abstract
The effects of 1.5 GHz electromagnetic near fields of time division multipl e access (TDMA) signal for the Personal Digital Cellular, Japanese cellular telephone standard (PDQ used for cellular phones, on mouse skin carcinogen esis initiated by 7,12-dimethylbenz[a]anthracene (DMBA) were examined. Ten- week-old ICR female mice were treated with a single application of DMBA on shaved dorsal skin by painting at a concentration of 100 mug/100 gl acetone per mouse. One week later, mice were divided into four groups, receiving e lectromagnetic near fields exposure (DMBA-EMF), sham-exposure (DMBA-Sham), 12-O-tetradecanoylphorbol-13-acetate (TPA, 4 mug/200 mu lacetone/mouse), as a positive control (DMBA-TPA), and no-treatment (DMBA-Control). EMF near f ields exposure conditions were as follows: skin local peak specific absorpt ion rate (SAR) 2.0 W/kg, whole body average SAR 0.084 W/kg (ratio of peak t o average SAR is 24), 90 min a day, 5 days a week, for 19 weeks. At week 20 , animals were killed and skin tumors were analyzed histopathologically. Th e incidences of skin tumors in DMBA-EMF, DMBA-Sham, DMBA-TPA and DMBA-Contr ol groups were 0/48 (0%), 0/48 (0%), 29/30 (96.6%) and 1/30 (3.3%), respect ively. Histopathologically, papilloma and squamous cell carcinoma (SCC) wer e observed in the DMBA-TPA group and only papilloma observed in the DMBA-Co ntrol group. The incidences of squamous cell papillomas and squamous cell c arcinomas in DMBA-TPA and DMBA-Control groups were 29/30 (96.6%) and 1130 ( 3.3%), respectively, numbers of tumors per mouse (tumor multiplicity) being 18.8 +/- 13.4 and 0.1 +/- 0.5. These data clearly demonstrated that near f ields exposure to 1.5 GHz EMF, used for cellular phones, does not exert any enhancing effect on skin tumorigenesis initiated by DMBA.