Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line

Shimo, T Kubota, S Kondo, S Nakanishi, T Sasaki, A Mese, H Matsumura, T Takigawa, M

T. Shimo et al., Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line, CANCER LETT, 174(1), 2001, pp. 57-64

34

INGLESE

Article

Onconogenesis & Cancer Research

CANCER LETTERS

0304-3835 → ACNP

174

1

2001

57 - 64

ISI

0304-3835(200112)174:1<57:CTGFAA>2.0.ZU;2-9

Connective tissue growth factor (CTGF) is known to be a potent angiogenic f actor. Here, we present the evidence that the hypoxic induction of angiogen esis by human breast cancer cells (MDA-231) can be ascribed at least in par t to CTGF, Our results indicate that (i) CTGF is abundantly present in MDA- 231 cells in vitro and in vivo, (ii) its secretion is up-regulated by hypox ia, and (iii) its gene expression is enhanced in MDA-231 cells cultured und er hypoxic conditions. These data suggest CTGF may stimulate angiogenesis b y paracrine mechanisms, thereby contributing to the invasion of breast canc er cells. This is the first evidence that human cancer cells differentially express CTGF protein and mRNA under the control of hypoxic conditions. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.