Genotoxic and non-genotoxic pathways of p53 induction

Citation
O. Pluquet et P. Hainaut, Genotoxic and non-genotoxic pathways of p53 induction, CANCER LETT, 174(1), 2001, pp. 1-15
Citations number
127
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
0304-3835 → ACNP
Volume
174
Issue
1
Year of publication
2001
Pages
1 - 15
Database
ISI
SICI code
0304-3835(200112)174:1<1:GANPOP>2.0.ZU;2-S
Abstract
Since the initial concept of p53 as a sensor of DNA-damage, the picture of the role of p53 has widened to include the sensing of much more diverse for ms of stress, including hypoxia and constitutive activation of growth-promo ting cascades. The pathways by which these processes regulate p53 are parti ally overlapping, but imply different patterns of post-translational modifi cations. In this review, we summarize current knowledge on post-translation al modifications of p53, and we discuss how hypoxia and oncogene activation stresses may induce p53 independently of DNA damage. (C) 2001 Elsevier Sci ence Ireland Ltd. All rights reserved.