Normal values for sincalide cholescintigraphy: Comparison of two methods

Citation
Ha. Ziessman et al., Normal values for sincalide cholescintigraphy: Comparison of two methods, RADIOLOGY, 221(2), 2001, pp. 404-410
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
RADIOLOGY
ISSN journal
0033-8419 → ACNP
Volume
221
Issue
2
Year of publication
2001
Pages
404 - 410
Database
ISI
SICI code
0033-8419(200111)221:2<404:NVFSCC>2.0.ZU;2-A
Abstract
PURPOSE: To establish normal gallbladder ejection fraction (GBEF) values fo r two sincalide (cholecystokinin [CCK]) infusion dose rates, 0.01 mug per k ilogram of body weight infused for 3 minutes and 0.01 mug/kg infused for 60 minutes. MATERIALS AND METHODS: Twenty healthy subjects were examined. GBEFs were ca lculated for the 3-minute infusion and for each 15-minute interval for the 60-minute infusion. Normal values were determined by using the mean +/- 2 S Ds and a more rigorous statistical analysis. RESULTS: With the 3-minute infusion, GBEFs were significantly more variable than with the 45- and 60-minute values for the 60-minute infusion (P <.01, .002). With intervals including 95% of the population, the GBEF lower norma l range was 16.8% for the 3-minute infusion but 31% and 41% for the 45- and 60-minute values, respectively. GBEFs of less than 35% were noted in six ( 30%) of 20 healthy subjects with the 3-minute infusion but in only one with the 60-minute infusion. Hepatobiliary ultrasonography was performed in six of seven subjects with GBEF of 36% or less, and US findings in all six wer e normal. CONCLUSION: A 3-minute infusion of sincalide, 0.01 <mu>g/kg, produces too v ariable a GBEF response to establish a clinically useful normal range. With 0.01 mug/kg infused for 60 minutes, clinically useful normal values were e stablished at 45 and 60 minutes.