The two-stage clonal expansion model as an example of a biologically basedmodel of radiation-induced cancer

Citation
Wf. Heidenreich et Hg. Paretzke, The two-stage clonal expansion model as an example of a biologically basedmodel of radiation-induced cancer, RADIAT RES, 156(5), 2001, pp. 678-681
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
RADIATION RESEARCH
ISSN journal
0033-7587 → ACNP
Volume
156
Issue
5
Year of publication
2001
Part
2
Pages
678 - 681
Database
ISI
SICI code
0033-7587(200111)156:5<678:TTCEMA>2.0.ZU;2-5
Abstract
A model with two stages and clonal expansion (TSCE) is reviewed as a protot ype for biologically based models of cancer development. Applications of th e TSCE model to data sets for animals and humans for particle radiation (a particles) are presented. The results suggest that the radiation not only i nfluences the initiating mutation, but may also act as a promoter. A possib le mechanism for the promoting action is described. The consequences of the se results for the shapes of the radiation dose-response curves at low dose s and dose rates are discussed. (C) 2001 by Radiation Research Society.