Risk estimation based on chromosomal aberrations induced by radiation

Citation
M. Durante et al., Risk estimation based on chromosomal aberrations induced by radiation, RADIAT RES, 156(5), 2001, pp. 662-667
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
RADIATION RESEARCH
ISSN journal
0033-7587 → ACNP
Volume
156
Issue
5
Year of publication
2001
Part
2
Pages
662 - 667
Database
ISI
SICI code
0033-7587(200111)156:5<662:REBOCA>2.0.ZU;2-5
Abstract
The presence of a causal association between the frequency of chromosomal a berrations in peripheral blood lymphocytes and the risk of cancer has been substantiated recently by epidemiological studies. Cytogenetic analyses of crew members of the Mir Space Station have shown that a significant increas e in the frequency of chromosomal aberrations can be detected after flight, and that such an increase is likely to be attributed to the radiation expo sure. The risk of cancer can be estimated directly from the yields of chrom osomal aberrations, taking into account some aspects of individual suscepti bility and other factors unrelated to radiation. However, the use of an app ropriate technique for the collection and analysis of chromosomes and the c hoice of the structural aberrations to be measured are crucial in providing sound results. Based on the fraction of aberrant lymphocytes detected befo re and after flight, the relative risk after a long-term Mir mission is est imated to be about 1.2-1.3. The new technique of mFISH can provide useful i nsights into the quantification of risk on an individual basis. (C) 2001 by Radiation Research Society.