Mutations in mammalian cells induced by heavy charged particles: An indicator for risk assessment in space

Citation
J. Kiefer et al., Mutations in mammalian cells induced by heavy charged particles: An indicator for risk assessment in space, RADIAT RES, 156(5), 2001, pp. 607-611
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
RADIATION RESEARCH
ISSN journal
0033-7587 → ACNP
Volume
156
Issue
5
Year of publication
2001
Part
2
Pages
607 - 611
Database
ISI
SICI code
0033-7587(200111)156:5<607:MIMCIB>2.0.ZU;2-R
Abstract
Induction of mutations at the HPRT locus in V79 Chinese hamster cells by he avy charged particles is reviewed. A unique dependence of mutation inductio n cross sections on LET or any other physical parameter of the particles ca nnot be found. There is, however, a general trend showing an increase up to about 100 keV/mum and an indication of a saturation with higher LET. An em pirical expression is given approximating the data which may be useful for practical purposes. On the basis of this expression, it is suggested that t he formula used by the ICRP for the quality factor overestimates the risk f or very heavy particles. This may have implications for the assessment of t he risk of exposure to iron ions in space. (C) 2001 by Radiation Research S ociety.