Probabilities of radiation-induced inter- and intrachromosomal exchanges and their dependence on the DNA content of the chromosome

Authors
Citation
Hl. Wu, Probabilities of radiation-induced inter- and intrachromosomal exchanges and their dependence on the DNA content of the chromosome, RADIAT RES, 156(5), 2001, pp. 603-606
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
RADIATION RESEARCH
ISSN journal
0033-7587 → ACNP
Volume
156
Issue
5
Year of publication
2001
Part
2
Pages
603 - 606
Database
ISI
SICI code
0033-7587(200111)156:5<603:PORIAI>2.0.ZU;2-B
Abstract
A biophysical model has been developed that is based on the assumptions tha t an interphase chromosome occupies a spherical territory and that chromoso me exchanges are formed by the misrejoining of two DNA double-strand breaks induced within a defined interaction distance. The model is used to explai n the relative frequencies of inter- and intrachromosomal exchanges and the relationship between radiation-induced aberrations in individual chromosom es and the DNA content of the chromosome. Although this simple model predic ts a higher ratio of inter- to intrachromosomal exchanges for low-LET radia tion than for high-LET radiation, as has been suggested by others, we argue that the comparison of the prediction of the model with experimental resul ts is not straightforward. With the model, we also show that the probabilit y of the formation of interchromosomal exchanges is proportional to the "su rface area" of the chromosome domain plus a correction term. The correction term is small if the interaction distance is less than 1 mum for both low- and high-LET radiations. (C) 2001 by Radiation Research Society.