Pathogenic significance and organic virus levels in patients infected withTT virus

Citation
F. Suzuki et al., Pathogenic significance and organic virus levels in patients infected withTT virus, INTERVIROLO, 44(5), 2001, pp. 291-297
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
INTERVIROLOGY
ISSN journal
0300-5526 → ACNP
Volume
44
Issue
5
Year of publication
2001
Pages
291 - 297
Database
ISI
SICI code
0300-5526(200109/10)44:5<291:PSAOVL>2.0.ZU;2-5
Abstract
Previous reports documented the recovery of a DNA virus from a patient with posttransfusion non-A-G hepatitis and named TT virus (TTV). Although the v irus was initially detected as a causative agent of hepatitis, there is dou bt about its pathogenicity. The aim of this study was to clarify the relati onship between TTV and liver diseases. Histopathological examination of liv er biopsies from 14 patients with TTV genotype 1 positive non-B, non-C and non-G chronic hepatitis showed mild fibrosis and periportal/piecemeal necro sis. Using the real-time detection (RTD)-PCR method, we found that TTV DNA levels of genotype 1 in liver samples from 3 such patients were 100- to 1,0 00-fold higher than those in the paired serum samples. Further investigatio n using various tissues from 2 autopsies of patients with hepatitis C with hepatocellular carcinoma revealed that the concentrations of TTV DNA in the liver were also higher than in serum samples. However, the highest TTV DNA concentrations in these 2 autopsies were found in the lung and bone marrow , respectively. Our results suggest that TTV may replicate in various tissu es including the liver and may cause only mild liver damage. Copyright (C) 2001 S. Karger AG, Basel.