Cancer risks in women with 2 breast or ovarian cancers: Clues to genetic cancer susceptibility

Citation
Hs. Evans et al., Cancer risks in women with 2 breast or ovarian cancers: Clues to genetic cancer susceptibility, INT J CANC, 94(5), 2001, pp. 758-759
Citations number
8
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF CANCER
ISSN journal
0020-7136 → ACNP
Volume
94
Issue
5
Year of publication
2001
Pages
758 - 759
Database
ISI
SICI code
0020-7136(200112)94:5<758:CRIWW2>2.0.ZU;2-#
Abstract
Women diagnosed with 2 cancers of the breast and/or ovary are at higher ris k of developing subsequent cancers. Using registrations from the Thames Can cer Registry, we quantified the risks at different cancer sites. Increased risks were found for cancers that are part of the BRCA1 and BRCA2 tumour sp ectrum: oropharyngeal cancer, malignant melanoma of the skin (BRCA2) and co lon cancer (BRCA1). We also found significantly increased risks of myeloid leukaemia (probably due to radiotherapy) and of cancer of the corpus uteri (which may be due to hormonal factors). (C) 2001 Wiley-Liss. Inc.