The effects of a selective noradrenaline reuptake inhibitor on the urethra: an in vitro and in vivo study

Citation
Jh. Bae et al., The effects of a selective noradrenaline reuptake inhibitor on the urethra: an in vitro and in vivo study, BJU INT, 88(7), 2001, pp. 771-775
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology
Journal title
BJU INTERNATIONAL
ISSN journal
1464-4096 → ACNP
Volume
88
Issue
7
Year of publication
2001
Pages
771 - 775
Database
ISI
SICI code
1464-4096(200111)88:7<771:TEOASN>2.0.ZU;2-N
Abstract
Objective To identify the effects of a selective noradrenaline reuptake inh ibitor (ventafaxine) on urethral perfusion pressure (UPP) in rabbits and ra ts, and thus assess its therapeutic potential for treating stress urinary i ncontinence. Materials and methods Strips of bladder and proximal urethra were prepared from female New Zealand White rabbits. Each strip was electrically stimulat ed and the contractile responses of controls strips compared with those aft er pretreatment with venlafaxine (100 mu mol/L). In separate experiments us ing 80 adult female Sprague-Dawley rats (250-300 g), changes in intravesica l pressure and UPP after the intra-arterial and intra-urethral administrati on of phenylephrine, phentolamine, fluoxetine and venlafaxine were monitore d using double-lumen catheters. Results Pretreatment with venlafaxine significantly decreased the contracti on of bladder strips (P=0.01) and significantly increased the contraction o f urethral strips (P = 0.008). In vivo, phenylephrine administered by both routes significantly increased UPP (P = 0.02); phentolamine (arterial) sign ificantly decreased UPP P = 0.001): fluoxetine (arterial) had no effect on UPP. and venlafaxine (both routes) significantly increased UPP (both P<0.00 1). The intravesical pressure was not changed significantly in any animal. Conclusions Venlafaxine effectively increased UPP both in vitro and in vivo : these results imply that venlafaxine may be useful for treating stress ur inary incontinence, by increasing the UPP.