Cytotoxic activities and structure-cytotoxic relationships of steroidal saponins

Citation
Y. Mimaki et al., Cytotoxic activities and structure-cytotoxic relationships of steroidal saponins, BIOL PHAR B, 24(11), 2001, pp. 1286-1289
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
0918-6158 → ACNP
Volume
24
Issue
11
Year of publication
2001
Pages
1286 - 1289
Database
ISI
SICI code
0918-6158(200111)24:11<1286:CAASRO>2.0.ZU;2-9
Abstract
We have systematically examined the cytotoxic activities of the steroidal s aponins mainly isolated from the Liliaceae plants against HL-60 human promy elocytic leukemia cells and found several structure-activity relationships. Some steroidal saponins evaluated in the assay system showed considerable cytotoxic activities, which were almost as potent as that of etoposide used as a positive control. The activities were found to be sensitive to the mo nosaccharides constituting the sugar moieties and their sequences, as well as to the structures of the aglycons.