Activation of mu-opioid pathway is associated with the canceling effect offootshock stimulus on the restraint stress-induced inhibition of small intestinal motility in rats

Citation
F. Tsukada et al., Activation of mu-opioid pathway is associated with the canceling effect offootshock stimulus on the restraint stress-induced inhibition of small intestinal motility in rats, BIOL PHAR B, 24(11), 2001, pp. 1332-1334
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
0918-6158 → ACNP
Volume
24
Issue
11
Year of publication
2001
Pages
1332 - 1334
Database
ISI
SICI code
0918-6158(200111)24:11<1332:AOMPIA>2.0.ZU;2-Z
Abstract
We previously reported that small intestinal motility was significantly inh ibited by restraint stress, but not by footshock stress. In the present stu dy, we found that plasma beta -endorphin levels were more significantly ele vated by footshock stress than restraint stress, and that preloading of foo tshock stimulus canceled the inhibition of small intestinal motility by res traint stress. Pretreatment with the mu -opioid receptor antagonist naltrex one significantly attenuated this canceling effect of footshock stimulus. T hese results suggest that footshock stimulus may cancel the inhibition of s mall intestinal motility by restraint stress via activation of mu -opioid r eceptors.