Activation of mu-opioid pathway is associated with the canceling effect offootshock stimulus on the restraint stress-induced inhibition of small intestinal motility in rats

Tsukada, F Ohuchi, Y Terunuma, T Sugawara, M Kohno, H Ohkubo, Y

F. Tsukada et al., Activation of mu-opioid pathway is associated with the canceling effect offootshock stimulus on the restraint stress-induced inhibition of small intestinal motility in rats, BIOL PHAR B, 24(11), 2001, pp. 1332-1334

27

INGLESE

Article

Pharmacology & Toxicology

BIOLOGICAL & PHARMACEUTICAL BULLETIN

0918-6158 → ACNP

24

11

2001

1332 - 1334

ISI

0918-6158(200111)24:11<1332:AOMPIA>2.0.ZU;2-Z

We previously reported that small intestinal motility was significantly inh ibited by restraint stress, but not by footshock stress. In the present stu dy, we found that plasma beta -endorphin levels were more significantly ele vated by footshock stress than restraint stress, and that preloading of foo tshock stimulus canceled the inhibition of small intestinal motility by res traint stress. Pretreatment with the mu -opioid receptor antagonist naltrex one significantly attenuated this canceling effect of footshock stimulus. T hese results suggest that footshock stimulus may cancel the inhibition of s mall intestinal motility by restraint stress via activation of mu -opioid r eceptors.