Relationship between cytotoxic activity and radical intensity of isoflavones from Sophora species

Citation
Y. Shirataki et al., Relationship between cytotoxic activity and radical intensity of isoflavones from Sophora species, ANTICANC R, 21(4A), 2001, pp. 2643-2648
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ANTICANCER RESEARCH
ISSN journal
0250-7005 → ACNP
Volume
21
Issue
4A
Year of publication
2001
Pages
2643 - 2648
Database
ISI
SICI code
0250-7005(200107/08)21:4A<2643:RBCAAR>2.0.ZU;2-O
Abstract
Among 11 isoflavones tested, genistein [YS13] produced higher cytotoxic act ivity against human oral tumor cell lines (HSC-2, HSG) than against normal cells (human gingival fibroblast, HGF), suggesting its tumor-specific actio n. Electron spin resonance (ESR) spectroscopy showed that YS13 did not prod uce radical, nor scavenged O-2. (-), generated by hypoxanthine-xanthine oxi dase reaction system, suggesting that radical-mediated oxidation mechanism is not be involved in the YS13-induced cytotoxicity. Addition of one prenyl group produced YS18 and YS19 with higher anti-Helicobacter pylori activity . Addition of two prenyl groups produced YS21 with the highest cytotoxic ac tivity but lower tumor-specificity. Since YS21 produced the highest amount of radical and most efficiently scavenged O-2. (-), this compound may induc e cytotoxicity by radical-mediated oxidation mechanism. All isoflavones fai led to induce anti-human immunodeficiency virus (HIV) activity. These data suggest the medicinal efficacy of isoflavones.