PROBLEM: It has been suggested that specific mechanisms commonly used by di
fferent cellular systems to evade immunologic recognition are involved in t
he development of endometriosis. To gain insight into this aspect, we looke
d at the relationship between two of these mechanisms in endometrial stroma
and the melanoma system for which the ability to create an environment of
immune privilege has been well established.
METHOD OF STUDY: Media conditioned by endometrial stromal cultures and mali
gnant melanoma A375 were examined to test their effects on peripheral blood
mononuclear cell-mediated cytotoxicity directed against K562 target. Moreo
ver, these media were tested for the concentration of the soluble form of i
ntercellular adhesion molecule-1 (sICAM-1), which has been suggested as a m
arker for spreading potential.
RESULTS: Media conditioned by endometrial stromal cultures exerted a signif
icant suppressive effect on cell cytotoxicity when compared with those deri
ved from malignant melanoma Moreover, the constitutive release of sICAM-1 w
as significantly higher in supernatants from endometrial stromal than in me
CONCLUSIONS: These results indicate that two specific properties suggested
to be involved in the ability of tumor cells to evade the immune system are
more pronounced in the endometrium than in a malignant melanoma. Since the
properties evaluated have been previously demonstrated to be even more not
able in endometrial samples derived from endometriosis patients. a role of
these mechanisms in the development of the disease may be hypothesized.