H. Matsubayashi et al., Different antiphospholipid antibody specificities are found in associationwith early repeated pregnancy loss versus recurrent IVF-failure patients, AM J REPROD, 46(5), 2001, pp. 323-329
PROBLEM: Patients having in vitro fertilization and embryo transfer (IVF-ET
) failures show an increased incidence of antiphospholipid (aPL) antibodies
; but controversy exists whether aPL can induce IVF-failure. This study was
designed to compare aPL specificities between recurrent IVF-failure patien
ts versus repeated early pregnancy loss (RPL) patients.
METHOD OF STUDY: Anticardiolipin (aCL), lupus anticoagulant (LA), antiphosp
hatidylserine (aPS), antiphosphatidylethanolamine (aPE), and antinuclear an
tibodies (ANA) were measured in 74 recurrent IVF-ET failure patients and co
mpared with 273 early RPL patients ( < 10 weeks).
RESULTS: An increased incidence of IgG-aPE and ANA was observed for both gr
oups in comparison with controls. Patients with recurrent IVF-ET failure sh
owed a significantly higher prevalence of IgG-aPS (P = 0.02) and IgG-aCL (P
= 0.02) when compared with early RPL patients or controls.
CONCLUSIONS: IgG-aPS and IgG-aCL may be responsible for some IVF-failures.
Additional studies are needed to clarify the pathogenic role of IgG-aPS and
IgG-aCL on IVF-ET failure.