Immunological hyperresponsiveness in HTLV-1 LTR-env-pX transgenic rats: A prototype animal model for collagen vascular and HTLV-I-related inflammatory diseases

Citation
Y. Nakamaru et al., Immunological hyperresponsiveness in HTLV-1 LTR-env-pX transgenic rats: A prototype animal model for collagen vascular and HTLV-I-related inflammatory diseases, PATHOBIOLOG, 69(1), 2001, pp. 11-18
Citations number
45
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
PATHOBIOLOGY
ISSN journal
1015-2008 → ACNP
Volume
69
Issue
1
Year of publication
2001
Pages
11 - 18
Database
ISI
SICI code
1015-2008(2001)69:1<11:IHIHLT>2.0.ZU;2-T
Abstract
We have earlier reported that diverse collagen vascular diseases, including arthritis, arteritis, thrombosis, myocarditis, myositis, sialo-/dacryoaden itis and dermatitis develop with the advent of autoantibodies in transgenic rats carrying the LTR-env-pX gene of human T lymphocyte virus type I (LTR- env-pX rats). To clarify the pathogenesis of these collagen vascular diseas es, immunological features of LTR-env-pX rats were examined. In LTR-env-pX rats affected with these diseases, expression of CD80/86 on both tissue-inf iltrating and peripheral T cells increased, compared with findings in non-t ransgenic rats with experimental inflammatory diseases. CD80/86 was also up regulated on peripheral T cells in LTR-env-pX rats prior to the development of diseases. Lymphocytes from LTR-env-pX rats showed an increase in autolo gous proliferation and were hyperreactive against several mitogens, includi ng concanavalin A, immobilized anti-CD3 antibodies, and superantigens in vi tro. Anti gen-specific immune response was also enhanced in LTR-env-pX rats . The collective evidence indicates that lymphocytes of LTR-env-pX rats con stitutively express surface molecules related to T cell activation and are immunologically hyperresponsive. Bone marrow cell transfer from LTR-env-pX rats to lethally irradiated non-transgenic rats revealed that these immunol ogically pre-activated and hyperresponsive lymphocytes play a critical role in the pathogenesis of several collagen vascular diseases, especially of d ermatitis in LTR-env-pX rats. Copyright (C) 2001 S. Karger AG, Basel.